The Dow Jones Industrial Average fell 1.72 points, or 0.01 percent, to end at 22,773.67, the S&P 500 lost 2.74 points, or 0.11 percent, to 2,549.33 and the Nasdaq Composite added 4.82 points, or 0.07 percent, to 6,590.18.
The S&P 500 eased on Friday, ending a six-day run of record highs as the first monthly decline in US nonfarm jobs in seven years dampened sentiment and pharmacy shares fell on Amazon competition fears.
The Nasdaq ended up for a ninth straight day, however, and set its sixth straight record high close, its longest such streak since seven records in February.
Walgreens Boots Alliance and CVS Health fell and were among the biggest drags on the S&P 500 after a CNBC report that Amazon was close to a decision on selling prescription drugs. Walgreens shares dropped 4.9 percent and CVS was down 4.9 percent, while Amazon shares rose 0.9 percent.
The Labor Department's closely watched jobs report showed nonfarm payrolls fell by 33,000 in September as hurricanes Harvey and Irma left displaced workers temporarily unemployed and delayed hiring. A bright spot was a better-than-expected rise in average wages.
"It's been amazing how resilient our U.S. stock market has been, going up on no news or bad news, so there's no surprise on a day where most people feel it was a mixed jobs report at best that the market actually is reacting in a way that makes sense," said Jake Dollarhide, chief executive officer of Longbow Asset Management in Tulsa, Oklahoma.
"It's a logical move for this illogical stock market."
The Dow Jones Industrial Average fell 1.72 points, or 0.01 percent, to end at 22,773.67, the S&P 500 lost 2.74 points, or 0.11 percent, to 2,549.33 and the Nasdaq Composite added 4.82 points, or 0.07 percent, to 6,590.18.
The benchmark's slight decline follow a six-day run of record closing highs, its longest since 1997.
The CBOE Volatility index , Wall Street's fear gauge, bounced sharply after setting a record low close in the previous session.
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